The beating heart of the Brazilian rainforest. This bustling frontier town emanates a verdigris grandeur, a throwback to the rubber boom gone by, illustrated best by the Belle Epoque opera house, with its marble halls and 198 Murano glass chandeliers. Drift away to the Philharmonic strains of Verdi or Mozart under frescoed ceilings in the midst of the steamy jungle. Outside, the inky Rio Negro meets but doesn’t merge with the more muddied Rio Solimoes, and pink dolphins, manatees and river otters ply the wide and winding waterways, the banks and jungle trails scattered with waterfalls, wild orchids, spider monkeys and jaguars.

The crystal-clear waters and fine white sands at this secluded Amazon beach town invite comparisons with the Caribbean. From this laid-back beguiling base, we might witness the peculiar Meeting of the Waters, as the mighty Amazon and clearer waters of the Rio Tapajos meet but don’t converge, continuing to flow instead side by side. Or stroll the little city of Santarem, with its Catholic cathedral and Sacred Arts Museum, and delve deep into the dense Tapajos National Forest, seeking jungle cats, giant armadillos, vibrant parrots and protected white-bellied spider monkeys.

Portal to the brilliant diversity of the Brazilian Amazon, the small city of Macapá – on the northern banks of the Amazon, at the mouth of the Atlantic – is considered the capital of the middle of the world. Place one foot in each hemisphere at the Marco Zero do Equador, a sundial that marks the equatorial line running through town, and head to Brazil’s largest fort, built in 1782, to understand Macapá’s past. As darkness falls, tune into the nocturnal jungle soundtrack, summoning a singular and seductive sense of place.

At first glance, Devil’s Island looks like paradise. Dotted with towering palm trees and surrounded by sparkling waters, this idyllic isle was once where Emperor Napoleon III imprisoned his enemies. Immortalised in “Papillon,” the hauntingly beautiful ruins hold secrets one shudders to imagine. Discover the mysteries for yourself on footpaths that ring the island and lead to ghostly churches built by prisoners. All that remains is the pristine jungle teaming with peacocks and monkeys, brilliant bougainvillea and butterflies. As you leave Devil’s Island, you realise you will forever be prisoner to its beauty.

Summon your inner Robinson Crusoe on remote Bequia. Secret lagoons. Castaway picnics. Warm waters in shades of blue that beg to be snorkelled through. Stake your flag in the sweet Bequia breeze just as the Union Jack did for almost 200 years. Usher in deep tranquillity on lovely Princess Margaret Beach. Ascend Mount Peggy with sunny views of St. Vincent. Stoll Belmont Boardwalk to Margret Beach for hand-whittled mahogany boat models then prowl the concrete catwalk that runs along Port Elizabeth for home-churned nutmeg ice cream. Support a sterling turtle sanctuary protecting the rare hawksbill or ferry to nearby Mustique, the favourite holiday romp for Prince William and Kate Middleton.

Gently breeze into the vibrant capital of Barbados. Steeped in fascinating history, with architecture to match, uncover the wonderfully laid-back West Indian ambiance. Embrace the slow Bajan rhythm of this welcoming island; surf, snorkel and try spotting turtles in balmy azure waters. Explore subterranean Harrison’s Cave, Jacobean St Nicholas Abbey and zipline high above bountiful tropical flora. Then return to restore on pastel pink sands at palm-studded beaches, where you’ll discover cocktail hour is endless, and measures of rum are copious.

Wind your way through the romantic island of St Lucia. Hike up the majestic UNESCO-listed Pitons, wallow in a volcanic mud bath, lounge on black sand beaches, explore botanical gardens and venture into a tropical jungle scattered with banana, coconut and mango plantations. Choose between calm Caribbean or choppy Atlantic seas to skim through waters by catamaran, private boat or kayak. Refresh beneath a waterfall, watch gliding whales and enjoy freshly caught mahi mahi with local Piton beer. Or just relax into an inner glow of serenity as you unwind in this tranquil tropical isle.

Mingle amongst other discerning guests on this French isle that exudes relaxed glamour. Wander along secluded beaches, harbourside Creole huts, drop into bohemian bars and snorkel gently through warm turquoise waters. Visit La Tourmente, the peaceful salt ponds and admire uninterrupted views on a local boat trip. And as you sip your second (or third) glass of champagne to the lull of the gentle waves, it might be time to learn the French for “paradise found”.

Formed by volcanoes, St Kitts fertile soil is so rich it turns monkeys green. Trek through miles of rainforest amongst colourful wildlife to conquer the highest peak of Mount Liamuiga so you can peer into the mile-wide crater, or bravely descend to sniff the sulphur. Experience a train ride, sailing trip, cooking class, sky safari zip-line, or creative batik fabric workshops. Visit sugarcane plantations, the Narrows between St Kitts and Nevis and the UNESCO Brimstone Hill Fortress for spectacular views of neighbouring islands. You’ll find this special island small in size yet tall in standing, as well as big on charm.

Explore the oldest US city for a dose of Caribbean history, slice of Spanish culture and twist of American dream. Roam historic Old San Juan alleyways to glimpse centuries-old forts and colourful colonial buildings. Learn how to move, as locals sashay out the salsa to rhythmic reggae beats. Shop the boho streets or glamorous boutiques for artisan goods, decadent designers and hand-rolled cigars. Experience world-class surfing, explore a tropical rainforest, attend a private rum cocktail tasting and polish off empanadas. Then retire to one of the beautiful beaches to soak up crystal clear waters and, perhaps, one last rum cocktail.